Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0H1UK
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| Drug Name |
MK-8591
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| Synonyms |
4'-Ethynyl-2-fluoro-2'-deoxyadenosine; UNII-QPQ082R25D; 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine; QPQ082R25D; 865363-93-5; 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine; (2R,3S,5R)-5-(6-amino-2-fluoro-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol; E2FdA; 2F-EdA; E2-FdA; AC1O5FTD; 4'Ed2FA; SCHEMBL2528556; CHEMBL517231; 4'-E-d2-FA; IKKXOSBHLYMWAE-QRPMWFLTSA-N; AKOS028113263; 4/'-Ethynyl-2-fluoro-2/'-deoxyadenosine; FT-0701326; Adenosine,2'-deoxy-4'-C-ethynyl-2-fluoro-; Adenosine, 2'-deoxy-4'-C-ethynyl-2-fluoro-; 9H-Purin-6-amine, 9-(2-deoxy-4-C-ethynyl-.
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62] | Phase 3 | [1] | |
| Company |
Merck Kenilworth, NJ
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| Structure |
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Download2D MOL |
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| Formula |
C12H12FN5O3
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| Canonical SMILES |
C#CC1(C(CC(O1)N2C=NC3=C(N=C(N=C32)F)N)O)CO
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| InChI |
1S/C12H12FN5O3/c1-2-12(4-19)6(20)3-7(21-12)18-5-15-8-9(14)16-11(13)17-10(8)18/h1,5-7,19-20H,3-4H2,(H2,14,16,17)/t6-,7+,12+/m0/s1
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| InChIKey |
IKKXOSBHLYMWAE-QRPMWFLTSA-N
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| CAS Number |
CAS 865363-93-5
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| PubChem Compound ID | ||||
| References | Top | |||
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| REF 1 | ClinicalTrials.gov (NCT04776252) Open-label, Follow-up of Doravirine/Islatravir for Participants With Human Immunodeficiency Virus -1 (HIV-1) Infection (MK-8591A-033). U.S. National Institutes of Health. | |||
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