Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H0EQ
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| Former ID |
DNAP001678
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| Drug Name |
Ponatinib
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| Synonyms |
Iclusig (TN)
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| Drug Type |
Small molecular drug
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| Indication | Acute lymphoblastic leukaemia [ICD-11: 2A85; ICD-10: C85.1, C88.7] | Approved | [1], [2] | |
| Company |
ARIAD Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C29H27F3N6O
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| Canonical SMILES |
CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
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| InChI |
1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
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| InChIKey |
PHXJVRSECIGDHY-UHFFFAOYSA-N
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| CAS Number |
CAS 943319-70-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
49848164, 57136216, 85267726, 85267727, 99437188, 103162345, 103768137, 104144064, 124757292, 125164096, 131480900, 135263267, 135626676, 135727465, 136350016, 136367447, 136368095, 136920265, 137245313, 137275996, 139832791, 144115614, 152134633, 152146116, 152258369, 160644559, 160647206, 162011539, 162037632, 162164010, 162164012, 162201514, 163209942, 164043013, 164187223, 164834148, 170503740, 172087035, 174006583, 174531620, 175266091, 175427142, 177749778, 178102513, 180371706, 185988972, 188899573, 196408591, 198993325, 204380154
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| ChEBI ID |
CHEBI:78543
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| ADReCS Drug ID | BADD_D01799 ; BADD_D01800 | |||
| SuperDrug ATC ID |
L01XE24
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| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5890). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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