Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0GK9J
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| Former ID |
DIB005190
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| Drug Name |
ACVR2B
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| Synonyms |
ACVR2B program (muscle atrophy); ACVR2B program (muscle atrophy), Rigel Pharmaceuticals; Activin type IIB receptorantagonist, (small molecule therapeutic, muscle atrophy), Rigel Pharmaceuticals
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| Indication | Muscle wasting disease [ICD-11: 8E4A.3; ICD-10: G13] | Investigative | [1] | |
| Company |
Rigel Pharmaceuticals Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Activin receptor type IIB (ACVR2B) | Target Info | Antagonist | [1] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| TGF-beta signaling pathway | ||||
| Signaling pathways regulating pluripotency of stem cells | ||||
| Panther Pathway | TGF-beta signaling pathway | |||
| Pathway Interaction Database | ALK1 signaling events | |||
| Reactome | Regulation of signaling by NODAL | |||
| WikiPathways | Mesodermal Commitment Pathway | |||
| Signaling by Activin | ||||
| Signaling by BMP | ||||
| Signaling by NODAL | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1792). | |||
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