Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0GG9W
|
|||
| Former ID |
DIB020076
|
|||
| Drug Name |
ISA-2011B
|
|||
| Synonyms |
ISA-2011B; 1395347-24-6; GTPL8444; SCHEMBL10020974; AKOS032946525; CS-6374
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C22H18ClN3O4
|
|||
| Canonical SMILES |
CN1CC(=O)N2C(C1=O)CC3=CC4=C(C=C3C2C5=CNC6=C5C=C(C=C6)Cl)OCO4
|
|||
| InChI |
1S/C22H18ClN3O4/c1-25-9-20(27)26-17(22(25)28)4-11-5-18-19(30-10-29-18)7-13(11)21(26)15-8-24-16-3-2-12(23)6-14(15)16/h2-3,5-8,17,21,24H,4,9-10H2,1H3/t17-,21-/m0/s1
|
|||
| InChIKey |
FSEZESVJDPKRDS-UWJYYQICSA-N
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | PtdIns(4)P-5-kinase 1 alpha (PIP5K1A) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. J Biol Chem. 1996 Dec 20;271(51):32937-43. | |||
| REF 2 | The role of PI3K/AKT-related PIP5K1alpha and the discovery of its selective inhibitor for treatment of advanced prostate cancer. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3689-98. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.