Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0GD5G
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| Former ID |
DNC010612
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| Drug Name |
H-KPPR-OH
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| Synonyms |
CHEMBL1091089; H-KPPR-OH
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|
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C22H40N8O5
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| Canonical SMILES |
C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCCN)N)C(=O)NC(CCCN=C(N)N)C(=O)O
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| InChI |
1S/C22H40N8O5/c23-10-2-1-6-14(24)19(32)30-13-5-9-17(30)20(33)29-12-4-8-16(29)18(31)28-15(21(34)35)7-3-11-27-22(25)26/h14-17H,1-13,23-24H2,(H,28,31)(H,34,35)(H4,25,26,27)/t14-,15-,16-,17-/m0/s1
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| InChIKey |
CKFCCXJQYNXYHI-QAETUUGQSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuropilin-1 (NRP1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Axon guidance | |||
| HTLV-I infection | ||||
| Panther Pathway | Axon guidance mediated by semaphorins | |||
| Pathway Interaction Database | VEGF and VEGFR signaling network | |||
| Plexin-D1 Signaling | ||||
| VEGFR1 specific signals | ||||
| Reactome | Neurophilin interactions with VEGF and VEGFR | |||
| CRMPs in Sema3A signaling | ||||
| CHL1 interactions | ||||
| WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| Signaling by VEGF | ||||
| Semaphorin interactions | ||||
| L1CAM interactions | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26. | |||
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