| Target and Pathway |
Top |
| Target(s) |
cGMP-dependent protein kinase (cGK) |
Target Info
|
Inhibitor |
[2] |
| Glycogen synthase kinase-3 beta (GSK-3B) |
Target Info
|
Inhibitor |
[1] |
| LCK tyrosine protein kinase (LCK) |
Target Info
|
Inhibitor |
[1] |
| MAP kinase p38 (MAPK12) |
Target Info
|
Inhibitor |
[1] |
| Protein kinase C alpha (PRKCA) |
Target Info
|
Inhibitor |
[1] |
| RAC-alpha serine/threonine-protein kinase (AKT1) |
Target Info
|
Inhibitor |
[1] |
| Ribosomal protein S6 kinase beta-1 (S6K1) |
Target Info
|
Inhibitor |
[1] |
| Stress-activated protein kinase 2a (p38 alpha) |
Target Info
|
Inhibitor |
[1] |
| Stress-activated protein kinase 2b (p38 beta) |
Target Info
|
Inhibitor |
[1] |
| Stress-activated protein kinase JNK1 (JNK1) |
Target Info
|
Inhibitor |
[1] |
|
KEGG Pathway
|
ErbB signaling pathway
|
|
HIF-1 signaling pathway
|
|
mTOR signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
AMPK signaling pathway
|
|
TGF-beta signaling pathway
|
|
Fc gamma R-mediated phagocytosis
|
|
Insulin signaling pathway
|
|
Proteoglycans in cancer
|
|
Acute myeloid leukemia
|
|
Choline metabolism in cancer
|
|
NF-kappa B signaling pathway
|
|
Osteoclast differentiation
|
|
Natural killer cell mediated cytotoxicity
|
|
T cell receptor signaling pathway
|
|
HTLV-I infection
|
|
Primary immunodeficiency
|
|
MAPK signaling pathway
|
|
Rap1 signaling pathway
|
|
FoxO signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Adrenergic signaling in cardiomyocytes
|
|
VEGF signaling pathway
|
|
Signaling pathways regulating pluripotency of stem cells
|
|
Platelet activation
|
|
Toll-like receptor signaling pathway
|
|
NOD-like receptor signaling pathway
|
|
RIG-I-like receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
TNF signaling pathway
|
|
Leukocyte transendothelial migration
|
|
Neurotrophin signaling pathway
|
|
Retrograde endocannabinoid signaling
|
|
Dopaminergic synapse
|
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Inflammatory mediator regulation of TRP channels
|
|
GnRH signaling pathway
|
|
Progesterone-mediated oocyte maturation
|
|
Prolactin signaling pathway
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
Shigellosis
|
|
Salmonella infection
|
|
Pertussis
|
|
Leishmaniasis
|
|
Chagas disease (American trypanosomiasis)
|
|
Toxoplasmosis
|
|
Tuberculosis
|
|
Hepatitis C
|
|
Influenza A
|
|
Epstein-Barr virus infection
|
|
Ras signaling pathway
|
|
Calcium signaling pathway
|
|
Phosphatidylinositol signaling system
|
|
Vascular smooth muscle contraction
|
|
Wnt signaling pathway
|
|
Focal adhesion
|
|
Tight junction
|
|
Gap junction
|
|
Circadian entrainment
|
|
Long-term potentiation
|
|
Glutamatergic synapse
|
|
Cholinergic synapse
|
|
Serotonergic synapse
|
|
GABAergic synapse
|
|
Long-term depression
|
|
Insulin secretion
|
|
Melanogenesis
|
|
Thyroid hormone synthesis
|
|
Thyroid hormone signaling pathway
|
|
Oxytocin signaling pathway
|
|
Aldosterone-regulated sodium reabsorption
|
|
Endocrine and other factor-regulated calcium reabsorption
|
|
Salivary secretion
|
|
Gastric acid secretion
|
|
Pancreatic secretion
|
|
Amphetamine addiction
|
|
Morphine addiction
|
|
Vibrio cholerae infection
|
|
Pathogenic Escherichia coli infection
|
|
African trypanosomiasis
|
|
Amoebiasis
|
|
Hepatitis B
|
|
Pathways in cancer
|
|
MicroRNAs in cancer
|
|
Glioma
|
|
Non-small cell lung cancer
|
|
cAMP signaling pathway
|
|
Protein processing in endoplasmic reticulum
|
|
Adipocytokine signaling pathway
|
|
Type II diabetes mellitus
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Herpes simplex infection
|
|
Colorectal cancer
|
|
Pancreatic cancer
|
|
Oocyte meiosis
|
|
cGMP-PKG signaling pathway
|
|
Chemokine signaling pathway
|
|
Apoptosis
|
|
Jak-STAT signaling pathway
|
|
B cell receptor signaling pathway
|
|
Estrogen signaling pathway
|
|
Glucagon signaling pathway
|
|
Regulation of lipolysis in adipocytes
|
|
Carbohydrate digestion and absorption
|
|
Measles
|
|
Renal cell carcinoma
|
|
Endometrial cancer
|
|
Prostate cancer
|
|
Melanoma
|
|
Chronic myeloid leukemia
|
|
Small cell lung cancer
|
|
Central carbon metabolism in cancer
|
|
Cell cycle
|
|
Hedgehog signaling pathway
|
|
Axon guidance
|
|
Hippo signaling pathway
|
|
Alzheimer's disease
|
|
Basal cell carcinoma
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
IL2 Signaling Pathway
|
|
IL5 Signaling Pathway
|
|
FSH Signaling Pathway
|
|
TNFalpha Signaling Pathway
|
|
TSH Signaling Pathway
|
|
Panther Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
PDGF signaling pathway
|
|
PI3 kinase pathway
|
|
p53 pathway by glucose deprivation
|
|
CCKR signaling map ST
|
|
Parkinson disease
|
|
T cell activation
|
|
Alzheimer disease-amyloid secretase pathway
|
|
Angiogenesis
|
|
B cell activation
|
|
EGF receptor signaling pathway
|
|
FGF signaling pathway
|
|
Interferon-gamma signaling pathway
|
|
Oxidative stress response
|
|
TGF-beta signaling pathway
|
|
Toll receptor signaling pathway
|
|
VEGF signaling pathway
|
|
Ras Pathway
|
|
p53 pathway feedback loops 2
|
|
p38 MAPK pathway
|
|
Alpha adrenergic receptor signaling pathway
|
|
Apoptosis signaling pathway
|
|
Endothelin signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
Wnt signaling pathway
|
|
5HT2 type receptor mediated signaling pathway
|
|
Histamine H1 receptor mediated signaling pathway
|
|
Oxytocin receptor mediated signaling pathway
|
|
Thyrotropin-releasing hormone receptor signaling pathway
|
|
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
|
FAS signaling pathway
|
|
Integrin signalling pathway
|
|
Huntington disease
|
|
Hypoxia response via HIF activation
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
Interleukin signaling pathway
|
|
p53 pathway
|
|
Alzheimer disease-presenilin pathway
|
|
Cadherin signaling pathway
|
|
Hedgehog signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Pathwhiz Pathway
|
Leucine Stimulation on Insulin Signaling
|
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Activation of PKC through G protein coupled receptor
|
|
Insulin Signalling
|
|
Pathway Interaction Database
|
Insulin Pathway
|
|
IL4-mediated signaling events
|
|
CDC42 signaling events
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
Regulation of Telomerase
|
|
mTOR signaling pathway
|
|
IGF1 pathway
|
|
IL2 signaling events mediated by PI3K
|
|
Integrins in angiogenesis
|
|
RXR and RAR heterodimerization with other nuclear receptor
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
|
a6b1 and a6b4 Integrin signaling
|
|
TGF-beta receptor signaling
|
|
Atypical NF-kappaB pathway
|
|
Glypican 1 network
|
|
TCR signaling in naï
|
|
|
|
Signaling events mediated by PTP1B
|
|
IL12-mediated signaling events
|
|
Regulation of p38-alpha and p38-beta
|
|
TCR signaling in naï
|
|
|
|
Thromboxane A2 receptor signaling
|
|
SHP2 signaling
|
|
IL2-mediated signaling events
|
|
CXCR4-mediated signaling events
|
|
Class I PI3K signaling events
|
|
amb2 Integrin signaling
|
|
EPHA forward signaling
|
|
PDGFR-beta signaling pathway
|
|
IL2 signaling events mediated by STAT5
|
|
Ephrin B reverse signaling
|
|
Alpha-synuclein signaling
|
|
Endothelins
|
|
BCR signaling pathway
|
|
p73 transcription factor network
|
|
p38 MAPK signaling pathway
|
|
CD40/CD40L signaling
|
|
FAS (CD95) signaling pathway
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
|
Glucocorticoid receptor regulatory network
|
|
Rapid glucocorticoid signaling
|
|
Regulation of Androgen receptor activity
|
|
ATF-2 transcription factor network
|
|
IL6-mediated signaling events
|
|
p38 signaling mediated by MAPKAP kinases
|
|
Retinoic acid receptors-mediated signaling
|
|
CXCR3-mediated signaling events
|
|
Signaling mediated by p38-alpha and p38-beta
|
|
EPO signaling pathway
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
p53 pathway
|
|
S1P2 pathway
|
|
Trk receptor signaling mediated by the MAPK pathway
|
|
VEGFR3 signaling in lymphatic endothelium
|
|
FGF signaling pathway
|
|
RAC1 signaling pathway
|
|
Regulation of retinoblastoma protein
|
|
Plasma membrane estrogen receptor signaling
|
|
Canonical NF-kappaB pathway
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Ras signaling in the CD4+ TCR pathway
|
|
ErbB1 downstream signaling
|
|
Syndecan-4-mediated signaling events
|
|
IL8- and CXCR2-mediated signaling events
|
|
VEGFR1 specific signals
|
|
PAR1-mediated thrombin signaling events
|
|
IL8- and CXCR1-mediated signaling events
|
|
Regulation of Ras family activation
|
|
Downstream signaling in naï
|
|
Fc-epsilon receptor I signaling in mast cells
|
|
RhoA signaling pathway
|
|
Noncanonical Wnt signaling pathway
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
Osteopontin-mediated events
|
|
Reelin signaling pathway
|
|
TRAIL signaling pathway
|
|
IL1-mediated signaling events
|
|
FoxO family signaling
|
|
Ceramide signaling pathway
|
|
p75(NTR)-mediated signaling
|
|
ErbB2/ErbB3 signaling events
|
|
JNK signaling in the CD4+ TCR pathway
|
|
Nephrin/Neph1 signaling in the kidney podocyte
|
|
HIV-1 Nef: Negative effector of Fas and TNF-alpha
|
|
Syndecan-2-mediated signaling events
|
|
N-cadherin signaling events
|
|
Signaling events mediated by focal adhesion kinase
|
|
Glypican 3 network
|
|
IL12 signaling mediated by STAT4
|
|
Signaling mediated by p38-gamma and p38-delta
|
|
Regulation of nuclear SMAD2/3 signaling
|
|
LPA receptor mediated events
|
|
S1P3 pathway
|
|
Coregulation of Androgen receptor activity
|
|
Integrin-linked kinase signaling
|
|
FOXA2 and FOXA3 transcription factor networks
|
|
E-cadherin signaling in the nascent adherens junction
|
|
IFN-gamma pathway
|
|
E-cadherin signaling in keratinocytes
|
|
Signaling events mediated by the Hedgehog family
|
|
Nongenotropic Androgen signaling
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
Caspase Cascade in Apoptosis
|
|
Aurora A signaling
|
|
Insulin-mediated glucose transport
|
|
Class I PI3K signaling events mediated by Akt
|
|
HIF-1-alpha transcription factor network
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
Degradation of beta catenin
|
|
Presenilin action in Notch and Wnt signaling
|
|
LKB1 signaling events
|
|
Canonical Wnt signaling pathway
|
|
C-MYC pathway
|
|
BMP receptor signaling
|
|
Validated transcriptional targets of deltaNp63 isoforms
|
|
Reactome
|
mTORC1-mediated signalling
|
|
GPVI-mediated activation cascade
|
|
PIP3 activates AKT signaling
|
|
Regulation of KIT signaling
|
|
Phosphorylation of CD3 and TCR zeta chains
|
|
Translocation of ZAP-70 to Immunological synapse
|
|
Generation of second messenger molecules
|
|
PECAM1 interactions
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
DAP12 signaling
|
|
CD28 co-stimulation
|
|
CD28 dependent PI3K/Akt signaling
|
|
CD28 dependent Vav1 pathway
|
|
CTLA4 inhibitory signaling
|
|
PD-1 signaling
|
|
Interleukin-2 signaling
|
|
NOD1/2 Signaling Pathway
|
|
p38MAPK events
|
|
ERK/MAPK targets
|
|
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
|
|
Oxidative Stress Induced Senescence
|
|
CDO in myogenesis
|
|
DSCAM interactions
|
|
ADP signalling through P2Y purinoceptor 1
|
|
Platelet sensitization by LDL
|
|
VEGFA-VEGFR2 Pathway
|
|
activated TAK1 mediates p38 MAPK activation
|
|
Activation of the AP-1 family of transcription factors
|
|
KSRP (KHSRP) binds and destabilizes mRNA
|
|
Calmodulin induced events
|
|
Disinhibition of SNARE formation
|
|
EGFR Transactivation by Gastrin
|
|
Inactivation, recovery and regulation of the phototransduction cascade
|
|
Syndecan interactions
|
|
Acetylcholine regulates insulin secretion
|
|
Ca2+ pathway
|
|
Trafficking of GluR2-containing AMPA receptors
|
|
G alpha (z) signalling events
|
|
Depolymerisation of the Nuclear Lamina
|
|
HuR (ELAVL1) binds and stabilizes mRNA
|
|
WNT5A-dependent internalization of FZD4
|
|
VEGFR2 mediated cell proliferation
|
|
Response to elevated platelet cytosolic Ca2+
|
|
NRAGE signals death through JNK
|
|
NRIF signals cell death from the nucleus
|
|
FCERI mediated MAPK activation
|
|
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
|
|
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
|
|
Activation of BAD and translocation to mitochondria
|
|
Translocation of GLUT4 to the plasma membrane
|
|
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
|
|
AKT phosphorylates targets in the cytosol
|
|
AKT phosphorylates targets in the nucleus
|
|
Negative regulation of the PI3K/AKT network
|
|
eNOS activation
|
|
AKT-mediated inactivation of FOXO1A
|
|
Integrin alphaIIb beta3 signaling
|
|
Deactivation of the beta-catenin transactivating complex
|
|
G beta:gamma signalling through PI3Kgamma
|
|
VEGFR2 mediated vascular permeability
|
|
TP53 Regulates Metabolic Genes
|
|
Constitutive Signaling by AKT1 E17K in Cancer
|
|
Degradation of beta-catenin by the destruction complex
|
|
Regulation of HSF1-mediated heat shock response
|
|
CRMPs in Sema3A signaling
|
|
Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
|
S33 mutants of beta-catenin aren't phosphorylated
|
|
S37 mutants of beta-catenin aren't phosphorylated
|
|
S45 mutants of beta-catenin aren't phosphorylated
|
|
T41 mutants of beta-catenin aren't phosphorylated
|
|
Degradation of GLI2 by the proteasome
|
|
WikiPathways
|
ErbB Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
G13 Signaling Pathway
|
|
IL-2 Signaling Pathway
|
|
Insulin Signaling
|
|
Cytoplasmic Ribosomal Proteins
|
|
EGF/EGFR Signaling Pathway
|
|
IL-4 Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Kit receptor signaling pathway
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
BDNF signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
TSH signaling pathway
|
|
Signaling by Insulin receptor
|
|
TOR Signaling
|
|
AMPK Signaling
|
|
IL-5 Signaling Pathway
|
|
Notch Signaling Pathway
|
|
Inflammatory Response Pathway
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Host Interactions of HIV factors
|
|
PIP3 activates AKT signaling
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
B Cell Receptor Signaling Pathway
|
|
TSLP Signaling Pathway
|
|
TCR signaling
|
|
Costimulation by the CD28 family
|
|
Toll-like receptor signaling pathway
|
|
Monoamine Transport
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
TCR Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
MAPK Cascade
|
|
Oxidative Stress
|
|
p38 MAPK Signaling Pathway
|
|
MAPK Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
Cardiac Hypertrophic Response
|
|
MAP kinase activation in TLR cascade
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
JAK/STAT
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Cardiac Progenitor Differentiation
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Parkinsons Disease Pathway
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
Prostate Cancer
|
|
TWEAK Signaling Pathway
|
|
RANKL/RANK Signaling Pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in leukocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
IL-1 signaling pathway
|
|
Signal amplification
|
|
Platelet homeostasis
|
|
NGF signalling via TRKA from the plasma membrane
|
|
Myogenesis
|
|
DSCAM interactions
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Angiogenesis
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathway
|
|
Calcium Regulation in the Cardiac Cell
|
|
Wnt Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
Wnt Signaling Pathway Netpath
|
|
G Protein Signaling Pathways
|
|
Transcriptional activation by NRF2
|
|
Myometrial Relaxation and Contraction Pathways
|
|
Human Complement System
|
|
Syndecan interactions
|
|
DAG and IP3 signaling
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Spinal Cord Injury
|
|
Pathogenic Escherichia coli infection
|
|
Signaling Pathways in Glioblastoma
|
|
Endothelin Pathways
|
|
Regulation of Microtubule Cytoskeleton
|
|
miRs in Muscle Cell Differentiation
|
|
Opioid Signalling
|
|
Response to elevated platelet cytosolic Ca2+
|
|
Integration of energy metabolism
|
|
DNA Damage Response (only ATM dependent)
|
|
FAS pathway and Stress induction of HSP regulation
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
NLR Proteins
|
|
IL-3 Signaling Pathway
|
|
EBV LMP1 signaling
|
|
PDGF Pathway
|
|
Nanoparticle triggered regulated necrosis
|
|
TNF alpha Signaling Pathway
|
|
Signalling by NGF
|
|
Intrinsic Pathway for Apoptosis
|
|
Apoptosis Modulation and Signaling
|
|
Type II diabetes mellitus
|
|
Osteoclast Signaling
|
|
Signal Transduction of S1P Receptor
|
|
Integrin-mediated Cell Adhesion
|
|
EPO Receptor Signaling
|
|
Endochondral Ossification
|
|
Copper homeostasis
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
Translocation of GLUT4 to the Plasma Membrane
|
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
|
Apoptosis
|
|
IL17 signaling pathway
|
|
IL-7 Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Integrated Cancer pathway
|
|
Metabolism of nitric oxide
|
|
TFs Regulate miRNAs related to cardiac hypertrophy
|
|
Androgen receptor signaling pathway
|
|
Glycogen Metabolism
|
|
Focal Adhesion
|
|
Hair Follicle Development: Induction (Part 1 of 3)
|
|
Degradation of beta-catenin by the destruction complex
|
|
Neural Crest Differentiation
|
|
Alzheimers Disease
|
|
Semaphorin interactions
|
|
Cell Cycle
|
