Drug Information
Drug General Information | Top | |||
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Drug ID |
D0G8FT
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Former ID |
DIB020365
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Drug Name |
ML204
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Synonyms |
5465-86-1; ML204; ML 204; 4-methyl-2-(piperidin-1-yl)quinoline; 4-Methyl-2-(1-piperidinyl)-quinoline; 4-methyl-2-piperidin-1-ylquinoline; 4-Methyl-2-(1-piperidinyl)quinoline; VU0024172-3; NSC25850; AC1Q4W9R; Cambridge id 5563912; AC1L5K4A; MLS001007138; 4-methyl-2-piperidylquinoline; 4-methyl-2-piperidinoquinoline; 2-Piperidino-4-methylquinoline; GTPL4255; cid_230710; 4-methyl-2-piperidino-quinoline; SCHEMBL14975993; CHEMBL1459962; CTK5A2131; BDBM77617; DTXSID30282438; EX-A938; AOB1526; MolPort-000-220-757; HMS2704E20; BCP28617
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C15H18N2
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Canonical SMILES |
CC1=CC(=NC2=CC=CC=C12)N3CCCCC3
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InChI |
1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3
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InChIKey |
USYRQXDHKXGTCK-UHFFFAOYSA-N
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CAS Number |
CAS 5465-86-1
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PubChem Compound ID | ||||
PubChem Substance ID |
86895, 3356884, 5621460, 9383217, 15763606, 24829278, 30030343, 50630616, 87713812, 97362164, 103140185, 104445559, 105585362, 117520929, 118407930, 125111603, 126463383, 130671417, 135568260, 142020966, 143964295, 162870448, 164058536, 168303981, 172892255, 178101072, 179215026, 239940260, 242263679, 244773323, 248873830, 252141322, 252158309, 252271935, 252450214, 252552001, 252654648
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Target and Pathway | Top | |||
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Target(s) | Short transient receptor potential channel 4 (TRPC4) | Target Info | Blocker (channel blocker) | [2] |
Short transient receptor potential channel 5 (TRPC5) | Target Info | Blocker (channel blocker) | [2] | |
Panther Pathway | Alzheimer disease-presenilin pathway | |||
Reactome | TRP channels | |||
Role of second messengers in netrin-1 signaling | ||||
WikiPathways | Netrin-1 signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4255). | |||
REF 2 | Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46. |
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