Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0G7TT
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| Former ID |
DIB019694
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| Drug Name |
D-AP4
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| Synonyms |
D-AP4; 78739-01-2; (2R)-2-amino-4-phosphonobutanoic acid; (R)-2-Amino-4-phosphonobutanoic acid; d(-)-2-amino-4-phosphonobutyric acid; Tocris-0101; Tocris-0102; D-APB; AC1LT3KN; Lopac-A-1910; GTPL1443; SCHEMBL12648443; CHEMBL1319383; CTK2I0929; BDBM82006; MolPort-004-956-473; ZINC1656225; PDSP1_000361; PDSP2_000359; BN0083; (r)-2-amino-4-phosphonobutyric acid; AKOS024456336; FCH3604711; API0009835; NCGC00024467-01; D-(-)-2-Amino-4-phosphonobutyric acid; NCGC00024466-01; NCGC00015041-02; NCGC00015041-01; B6201; FT-0772107; Butanoic acid, 2
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C4H10NO5P
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| Canonical SMILES |
C(CP(=O)(O)O)C(C(=O)O)N
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| InChI |
1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m1/s1
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| InChIKey |
DDOQBQRIEWHWBT-GSVOUGTGSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 8 (mGluR8) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glutamatergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Metabotropic glutamate receptor group III pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1443). | |||
| REF 2 | Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97. | |||
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