Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G3AR
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| Former ID |
DIB004587
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| Drug Name |
CX-717
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| Synonyms |
CX-1763; CX-546; CX-614; CX-727; CX-729; CX-743; CX-815; S-40929; First generation AMPA receptor modulators, Cortex/University of California; First-generation AMPAKINE compounds, University of California/Cortex
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| Drug Type |
Small molecular drug
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| Indication | Spinal cord injury [ICD-11: ND51.2] | Phase 2 | [1] | |
| Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Preclinical | [2], [3] | ||
| Company |
University of California
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| Structure |
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Download2D MOL |
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| Formula |
C11H11N3O3
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| Canonical SMILES |
C1COCCN1C(=O)C2=CC3=NON=C3C=C2
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| InChI |
1S/C11H11N3O3/c15-11(14-3-5-16-6-4-14)8-1-2-9-10(7-8)13-17-12-9/h1-2,7H,3-6H2
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| InChIKey |
KFRQROSRKSVROW-UHFFFAOYSA-N
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| CAS Number |
CAS 211735-82-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11972335, 14798527, 43042116, 57370278, 80251346, 99004853, 103722803, 123109526, 126729553, 135246548, 135374429, 137000037, 139458664, 144240095, 152053440, 160834641, 162221096, 163096646, 163401101, 164207460, 164836141, 172913315, 204384250, 223366172, 223379109, 223662915, 226972920, 247914918, 249864782, 250209617, 251897220, 252073141, 252158640, 252434304, 252514106
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate receptor AMPA (GRIA) | Target Info | Modulator | [4] |
| References | Top | |||
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| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7842). | |||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013391) | |||
| REF 4 | Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep. J Psychopharmacol. 2012 Aug;26(8):1047-57. | |||
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