Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0G2XR
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| Former ID |
DIB009920
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| Drug Name |
TCD-717
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| Synonyms |
Choline kinase alpha inhibitor (iv, solid tumors), TCD Pharma
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
TCD Pharma
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| Structure |
 |
Download2D MOL
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| Formula |
C46H38Cl2N4+2
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| Canonical SMILES |
CN(C1=CC=C(C=C1)Cl)C2=CC=[N+](C3=CC=CC=C32)CC4=CC=C(C=C4)C5=CC=C(C=C5)C[N+]6=CC=C(C7=CC=CC=C76)N(C)C8=CC=C(C=C8)Cl
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| InChI |
1S/C46H38Cl2N4/c1-49(39-23-19-37(47)20-24-39)43-27-29-51(45-9-5-3-7-41(43)45)31-33-11-15-35(16-12-33)36-17-13-34(14-18-36)32-52-30-28-44(42-8-4-6-10-46(42)52)50(2)40-25-21-38(48)22-26-40/h3-30H,31-32H2,1-2H3/q+2
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| InChIKey |
QGYGTMZEJNOHNU-UHFFFAOYSA-N
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| CAS Number |
CAS 850993-73-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Choline kinase (CHKA) | Target Info | Inhibitor | [2] |
| BioCyc | Phosphatidylcholine biosynthesis | |||
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Metabolic pathways | ||||
| Choline metabolism in cancer | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| WikiPathways | Acetylcholine Synthesis | |||
| Glycerophospholipid biosynthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01215864) Study of Intravenous TCD-717 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health. | |||
| REF 2 | National Cancer Institute Drug Dictionary (drug id 687183). | |||
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