Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G1SN
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| Former ID |
DNC001611
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| Drug Name |
ED1
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| Synonyms |
ethylenediamine scaffold, 10; BDBM31426; ED1; 3-{2'-[{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)sulfamoyl]biphenyl-3-yl}propanoic acid
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| Drug Type |
Aptamer
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| Indication | Acute respiratory distress syndrome [ICD-11: CB00; ICD-10: J80] | Investigative | [1] | |
| Myocardial reperfusion injury [ICD-11: NB31] | Investigative | [1] | ||
| Sepsis [ICD-11: 1G40-1G41] | Investigative | [1] | ||
| Structure |
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Download2D MOL |
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| Canonical SMILES |
CC(C)(C)OC(=O)N1CCC(CC1)CN(CCN(CC2=CN=CN2C)C3=CC=C(C=C3)C#N)S(=O)(=O)C4=CC=CC=C4C5=CC=CC(=C5)CCC(=O)O
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neutrophil elastase (NE) | Target Info | . | [1] |
| KEGG Pathway | Transcriptional misregulation in cancer | |||
| Systemic lupus erythematosus | ||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| C-MYB transcription factor network | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| Human Complement System | ||||
| Degradation of collagen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. | |||
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