Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FQ2U
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| Former ID |
DIB005907
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| Drug Name |
Talabostat
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| Synonyms |
Talabostat mesylate; Boroproline compounds, DARA BioSciences; Boroproline compounds, Point Therapeutics; PT-100; Val-boro-Pro
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| Drug Type |
Small molecular drug
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| Indication | Constitutional neutropenia [ICD-11: 4B00.0] | Phase 3 | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [2] | ||
| Company |
Point Therapeutics; Tufts University School of Medicine
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| Structure |
 |
Download2D MOL
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| Formula |
C9H19BN2O3
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| Canonical SMILES |
B(C1CCCN1C(=O)C(C(C)C)N)(O)O
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| InChI |
1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8-/m0/s1
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| InChIKey |
FKCMADOPPWWGNZ-YUMQZZPRSA-N
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| CAS Number |
CAS 149682-77-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dipeptidyl peptidase 8 (DPP-8) | Target Info | Inhibitor | [2] |
| Dipeptidyl peptidase 9 (DPP-9) | Target Info | Inhibitor | [2] | |
| Prolyl endopeptidase FAP (FAP) | Target Info | Inhibitor | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer. Cancer Biol Ther. 2007 Nov;6(11):1691-9. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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