Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0FQ1Z
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| Former ID |
DNC003888
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| Drug Name |
GNF-PF-4292
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| Synonyms |
Hydrocinchonine; GNF-PF-4292; CHEMBL428695; Cinchotine; (8alpha,9R)-10,11-Dihydrocinchonan-9-ol; 485-64-3; Cinchonifine; Pseudocinchonine; y-Cinchonine; 10,11-dihydrocinchonan-9-ol; (9S)-10,11-Dihydrocinchonan-9-ol; 10,11-dihydrocinchonine; AC1Q4XW7; AC1L2RE5; Oprea1_425428; SCHEMBL312806; MolPort-003-871-861; WFJNHVWTKZUUTR-UHFFFAOYSA-N; BDBM50047001; NCGC00142479-01; AC-30196; ST056343; FT-0700733; (9S)-10,11-Dihydrocinchonan-9-ol, 9CI; (1R)(5-ethylquinuclidin-2-yl)-4-quinolylmethan-1-ol; Quinoline 4-(alpha-(7-ethyl-1,4-ethanopip
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H24N2O
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| Canonical SMILES |
CCC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O
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| InChI |
1S/C19H24N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h3-7,9,13-14,18-19,22H,2,8,10-12H2,1H3
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| InChIKey |
WFJNHVWTKZUUTR-UHFFFAOYSA-N
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| CAS Number |
CAS 485-64-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Debrisoquine 4-hydroxylase (CYP2D6) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Metabolism of xenobiotics by cytochrome P450 | |||
| Drug metabolism - cytochrome P450 | ||||
| Serotonergic synapse | ||||
| Reactome | Xenobiotics | |||
| WikiPathways | Metapathway biotransformation | |||
| Tamoxifen metabolism | ||||
| Oxidation by Cytochrome P450 | ||||
| Vitamin D Receptor Pathway | ||||
| Aripiprazole Metabolic Pathway | ||||
| Fatty Acid Omega Oxidation | ||||
| Codeine and Morphine Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. 1993 Apr 30;36(9):1136-45. | |||
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