Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FC4Y
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| Former ID |
DIB019442
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| Drug Name |
PMID22902653C31
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| Synonyms |
BMS 4; GTPL8117; MolPort-042-665-786; ZINC84707544; BDBM50390791; NCGC00372509-03
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C23H23N7O2S
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| Canonical SMILES |
CCNC(=O)NC1=NC=C(S1)C2=CC(=NC(=N2)C3=NC=CN=C3)C4=C(C=C(C=C4C)OC)C
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| InChI |
1S/C23H23N7O2S/c1-5-25-22(31)30-23-27-12-19(33-23)16-10-17(20-13(2)8-15(32-4)9-14(20)3)29-21(28-16)18-11-24-6-7-26-18/h6-12H,5H2,1-4H3,(H2,25,27,30,31)
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| InChIKey |
WUCYRTXFXRZKSV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | LIM domain kinase-1 (LIMK-1) | Target Info | Inhibitor | [2] |
| LIM domain kinase-2 (LIMK-2) | Target Info | Inhibitor | [2] | |
| Testis-specific kinase 1 (TESK1) | Target Info | Inhibitor | [2] | |
| Testis-specific kinase 2 (TESK2) | Target Info | Inhibitor | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. J Biol Chem. 2001 Aug 17;276(33):31449-58. | |||
| REF 2 | Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. | |||
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