Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0FC2D
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| Drug Name |
Dec-RVKR-CMK
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| Synonyms |
AKOS024457645; DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE; Decanoyl-Arg-Val-Lys-Arg-chloromethylketone trifluoroacetate salt; ZINC98052548; decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone
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| Drug Type |
Protein/peptide drug
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| Indication | Middle East Respiratory Syndrome (MERS) [ICD-11: 1D64] | Preclinical | [1], [2] | |
| Therapeutic Class |
Antiviral Agents
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| Structure |
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Download2D MOL
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| Canonical SMILES |
CCCCCCCCCC(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCN=C(N)N)C(=O)CCl
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN dibasic-processing enzyme (Furin) | Target Info | Blocker | [1], [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. | |||
| REF 2 | Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15214-9. | |||
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