Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F9WF
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| Former ID |
DIB011271
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| Drug Name |
SINOMENINE
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| Synonyms |
Cucoline; Kukoline; (9alpha,13alpha,14alpha)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one
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| Drug Type |
Small molecular drug
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| Indication | Arthritis [ICD-11: FA20] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H23NO4
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| Canonical SMILES |
CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC
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| InChI |
1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,19-/m1/s1
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| InChIKey |
INYYVPJSBIVGPH-QHRIQVFBSA-N
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| CAS Number |
CAS 115-53-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:9163
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | NADPH oxidase (NOX) | Target Info | Modulator | [2] |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Phagosome | ||||
| Osteoclast differentiation | ||||
| Leukocyte transendothelial migration | ||||
| Pathway Interaction Database | RAC1 signaling pathway | |||
| WikiPathways | Vitamin D Receptor Pathway | |||
| TNF alpha Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008290) | |||
| REF 2 | Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation. 2007 Sep 19;4:23. | |||
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