Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F8XI
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| Former ID |
DNCL003436
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| Drug Name |
DS-1442
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| Indication | Dyslipidemia [ICD-11: 5C80-5C81; ICD-9: 272] | Discontinued in Phase 1 | [1] | |
| Company |
Daiichi Sankyo
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| Structure |
 |
Download2D MOL |
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| Formula |
C10H7NO2
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| Canonical SMILES |
C1=CC2=C(C=CN=C2)C(=C1)C(=O)O
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| InChI |
1S/C10H7NO2/c12-10(13)9-3-1-2-7-6-11-5-4-8(7)9/h1-6H,(H,12,13)
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| InChIKey |
ZIPLFLRGHZAXSJ-UHFFFAOYSA-N
|
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| CAS Number |
CAS 27810-64-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cholesteryl ester transfer protein (CETP) | Target Info | Modulator | [2] |
| Panther Pathway | CCKR signaling map ST | |||
| Reactome | LDL-mediated lipid transport | |||
| HDL-mediated lipid transport | ||||
| WikiPathways | Statin Pathway | |||
| Lipid digestion, mobilization, and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036983) | |||
| REF 2 | Ds-1442b is a Novel, Potent Cetp Inhibitor That Reduces Atherosclerosis by Hdl Elevation and Non-hdl Reduction. Circulation. 2012; 126: A11806. | |||
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