Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F5VD
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| Former ID |
DNCL003497
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| Drug Name |
Ezatiostat
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| Synonyms |
Telintra (TN)
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| Drug Type |
Small molecular drug
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| Indication | Myelodysplastic syndrome [ICD-11: 2A37; ICD-9: 238.7] | Phase 2 | [1] | |
| Company |
Telik
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H35N3O6S
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| Canonical SMILES |
CCOC(=O)C(CCC(=O)NC(CSCC1=CC=CC=C1)C(=O)NC(C2=CC=CC=C2)C(=O)OCC)N
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| InChI |
1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
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| InChIKey |
GWEJFLVSOGNLSS-WPFOTENUSA-N
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| CAS Number |
CAS 168682-53-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutathione S-transferase P (GSTP1) | Target Info | Modulator | [2] |
| BioCyc | Glutathione-mediated detoxification | |||
| 4-hydroxy-2-nonenal detoxification | ||||
| KEGG Pathway | Glutathione metabolism | |||
| Metabolism of xenobiotics by cytochrome P450 | ||||
| Drug metabolism - cytochrome P450 | ||||
| Pathways in cancer | ||||
| Chemical carcinogenesis | ||||
| Prostate cancer | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01422486) Phase 2 Study of Telintra in Deletion 5q Myelodysplastic Syndrome. U.S. National Institutes of Health. | |||
| REF 2 | National Cancer Institute Drug Dictionary (drug id 485244). | |||
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