Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F5KY
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| Former ID |
DIB019669
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| Drug Name |
CX4
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| Synonyms |
AC1MBGFP; Maybridge4_002933; CX-4; GTPL7663; CCG-196; MolPort-002-912-245; HMS1529F07; MCULE-4373871510; NCGC00176395-01; BRD-A62325689-001-01-9; 1-(2-chloro-6-methylphenyl)-3-(1,2-diphenylethyl)thiourea
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H21ClN2S
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| Canonical SMILES |
CC1=C(C(=CC=C1)Cl)NC(=S)NC(CC2=CC=CC=C2)C3=CC=CC=C3
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| InChI |
1S/C22H21ClN2S/c1-16-9-8-14-19(23)21(16)25-22(26)24-20(18-12-6-3-7-13-18)15-17-10-4-2-5-11-17/h2-14,20H,15H2,1H3,(H2,24,25,26)
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| InChIKey |
LHTLPGOZLLOCIS-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated potassium channel Kv12.2 (KCNH3) | Target Info | Inhibitor (gating inhibitor) | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7663). | |||
| REF 2 | Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep;13(9):1056-8. | |||
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