Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F2JS
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| Former ID |
DCL000085
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| Drug Name |
CHR-2797
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| Synonyms |
Tosedostat; Tosedostat, CHR2797, CHR-2797
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| Drug Type |
Small molecular drug
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 2 | [1], [2] | |
| Myelodysplastic syndrome [ICD-11: 2A37; ICD-9: 238.7] | Phase 2 | [2] | ||
| Inflammation [ICD-11: 1A00-CA43.1] | Terminated | [3] | ||
| Therapeutic Class |
Anticancer Agents
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| Company |
Chroma Therape.
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| Structure |
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Download2D MOL |
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| Formula |
C21H30N2O6
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| Canonical SMILES |
CC(C)CC(C(C(=O)NO)O)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2
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| InChI |
1S/C21H30N2O6/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-3-5-9-14)21(27)29-15-10-6-7-11-15/h3-5,8-9,13,15-18,24,28H,6-7,10-12H2,1-2H3,(H,22,25)(H,23,26)/t16-,17+,18+/m1/s1
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| InChIKey |
FWFGIHPGRQZWIW-SQNIBIBYSA-N
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| CAS Number |
CAS 238750-77-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
50094128, 85197633, 85886759, 99437203, 124757313, 125164117, 126666918, 135264670, 135626746, 135698865, 135727437, 136348239, 136367534, 136367991, 137276019, 140102605, 144115826, 152344443, 160708510, 162037644, 162202731, 163126223, 164023428, 164194097, 164765662, 177748695, 184824039, 198964464, 204377611, 223665363, 223704697, 241054287, 241376540, 243220305, 252157386, 252451524
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| ChEBI ID |
CHEBI:95044
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aminopeptidase (AMP) | Target Info | Inhibitor | [2] |
| Puromycin-sensitive aminopeptidase (NPEPPS) | Target Info | Inhibitor | [4] | |
| Reactome | Antigen processing: Ubiquitination & Proteasome degradation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022187) | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014340) | |||
| REF 4 | CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 2008 Aug 15;68(16):6669-79. | |||
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