Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F1PH
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| Former ID |
DIB008663
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| Drug Name |
Rimeporide
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| Synonyms |
EMD-87580; EMR-204; EMR-62204; NHE inhibitors (atrial fibrillation), Merck KGaA; Sodium/hydrogen exchange inhibitors (atrial fibrillation), Merck KGaA
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| Drug Type |
Small molecular drug
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| Indication | Myocardial infarction [ICD-11: BA41-BA43; ICD-9: 410] | Investigative | [1] | |
| Company |
Merck KGaA
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H15N3O5S2
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| Canonical SMILES |
CC1=CC(=C(C=C1C(=O)N=C(N)N)S(=O)(=O)C)S(=O)(=O)C
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| InChI |
1S/C11H15N3O5S2/c1-6-4-8(20(2,16)17)9(21(3,18)19)5-7(6)10(15)14-11(12)13/h4-5H,1-3H3,(H4,12,13,14,15)
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| InChIKey |
GROMEQPXDKRRIE-UHFFFAOYSA-N
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| CAS Number |
CAS 187870-78-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium/hydrogen exchanger (SLC) | Target Info | Inhibitor | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Cardiac muscle contraction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Regulation of actin cytoskeleton | ||||
| Thyroid hormone signaling pathway | ||||
| Salivary secretion | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| Proteoglycans in cancer | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800042366) | |||
| REF 2 | Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. Circulation. 2007 Mar 6;115(9):1090-100. | |||
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