Drug Information
Drug General Information | Top | |||
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Drug ID |
D0EV1I
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Former ID |
DNC009281
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Drug Name |
C-014C
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Synonyms |
C-014C; CHEMBL509396; BDBM50244050
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C22H32N4O2
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Canonical SMILES |
COC1=C(C=C2C(=C1)C(=NC(=N2)NC3CCCC3)NC4CCCCCC4)OC
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InChI |
1S/C22H32N4O2/c1-27-19-13-17-18(14-20(19)28-2)25-22(24-16-11-7-8-12-16)26-21(17)23-15-9-5-3-4-6-10-15/h13-16H,3-12H2,1-2H3,(H2,23,24,25,26)
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InChIKey |
HZBKRPBMAVNOCZ-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | C-C chemokine receptor type 4 (CCR4) | Target Info | Inhibitor | [1] |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
Chemokine signaling pathway | ||||
Viral carcinogenesis | ||||
Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
Reactome | Chemokine receptors bind chemokines | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines. Bioorg Med Chem. 2008 Jul 15;16(14):7021-32. |
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