Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0EP8X
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| Former ID |
DAP001311
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| Drug Name |
Gamma Hydroxybutyric Acid
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| Synonyms |
Anetamin; GHB; Hydroxyb; Oxybate; SHB; Somsanit; Xyrem; Gamma OH; Oxybate sodium; Utyric acid monosodium salt; EB 27; WY 3478; Gam-OH; Gamma-Hydroxy butyrate; Gamma-Hydroxy sodium butyrate; Gamma-Hydroxybutanoic acid; Gamma-Hydroxybutyrate sodium; Gamma-Hydroxybutyric acid; Gamma-Hydroxybutyric acid decomposition product; Gamma-Hydroxybutyric acid monosodium salt; Gamma-OH; Xyrem (TN); Gamma-Hydroxybutyric acid, sodium salt; Oxy-n-butyric acid; Sodium Oxybate (4-hydroxybutanoic acid); Sodium .gamma.-hydroxybutyrate; Sodium .gamma.-oxybutyrate; AA3E2AF0-AB7A-4A1E-A391-199C049D7162; Butanoic acid, 4-hydroxy-, monosodium salt; Butanoic acid, 4-hydroxy-, sodium salt; Butyric acid, 4-hydroxy-, monosodium salt; Butyric acid, 4-hydroxy-, sodium salt; 3-carboxypropoxy acid; 4 HB; 4-Hydroxy; 4-Hydroxyacid; 4-Hydroxyalkanoic acid; 4-Hydroxybutanoic acid; 4-Hydroxybuttersaeure; 4-Hydroxybutyrate sodium; 4-Hydroxybutyric acid; 4-Hydroxybutyric acid monosodium salt; 4-Hydroxycarboxylic acid; 4-OHB; 4-hydroxy-butyric acid
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| Drug Type |
Small molecular drug
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| Indication | Narcolepsy [ICD-11: 7A20; ICD-10: G47.4] | Approved | [1], [2] | |
| Therapeutic Class |
Anesthetics
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| Company |
Jazz Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C4H8O3
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| Canonical SMILES |
C(CC(=O)O)CO
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| InChI |
1S/C4H8O3/c5-3-1-2-4(6)7/h5H,1-3H2,(H,6,7)
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| InChIKey |
SJZRECIVHVDYJC-UHFFFAOYSA-N
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| CAS Number |
CAS 591-81-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4235, 5088, 794561, 5247515, 7850105, 8145213, 8157522, 10528636, 15146413, 29228914, 29452282, 32853538, 42867017, 47440777, 48185497, 49896246, 57326193, 74490173, 92297559, 103429626, 103933987, 104223670, 104323225, 124954082, 125653427, 126523504, 128286695, 128496528, 129247383, 134224814, 134977465, 135156947, 137005507, 142455246, 160964707, 162833579, 175268868, 178101422, 179293029, 216232054, 223671530, 223922918, 226401522, 241064153, 241101175, 249900959
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| ChEBI ID |
CHEBI:30830
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| SuperDrug ATC ID |
N01AX11; N07XX04
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| SuperDrug CAS ID |
cas=000591811
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Modulator | [3] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4711). | |||
| REF 2 | Sodium oxybate: a review of its use in the management of narcolepsy. CNS Drugs. 2007;21(4):337-54. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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