Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0EO3S
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| Drug Name |
Chalcone derivative 2
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| Synonyms |
PMID28454500-Compound-17
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| Drug Type |
Small molecular drug
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| Company |
CUREVEDA, LLC
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H12F3NO2
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| Canonical SMILES |
COC1=C(C=NC=C1)C(=O)C=CC2=CC=CC=C2C(F)(F)F
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| InChI |
1S/C16H12F3NO2/c1-22-15-8-9-20-10-12(15)14(21)7-6-11-4-2-3-5-13(11)16(17,18)19/h2-10H,1H3/b7-6+
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| InChIKey |
ZYPJWXKOHCZQCI-VOTSOKGWSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cysteines of Keap1 (KEAP1 Cysteines) | Target Info | Modulator | [1] |
| Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target Info | Activator | [1] | |
| Target's Patent Info | Cysteines of Keap1 (KEAP1 Cysteines) | Target's Patent Info | [1] | |
| Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target's Patent Info | [1] | ||
| KEGG Pathway | Protein processing in endoplasmic reticulum | |||
| NetPath Pathway | IL5 Signaling Pathway | |||
| WikiPathways | Oxidative Stress | |||
| Transcriptional activation by NRF2 | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Aryl Hydrocarbon Receptor Pathway | ||||
| Mesodermal Commitment Pathway | ||||
| Aryl Hydrocarbon Receptor | ||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | ||||
| Arylhydrocarbon receptor (AhR) signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. | |||
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