Drug Information
Drug General Information | Top | |||
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Drug ID |
D0EO2C
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Former ID |
DIB012871
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Drug Name |
LY-2881835
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Drug Type |
Small molecular drug
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Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Phase 1 | [1] | |
Company |
Eli Lilly & Co
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Structure |
Download2D MOL |
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Formula |
C33H33NO3
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Canonical SMILES |
CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(C=C2)CN3CCC4(CC3)C=CC5=CC=CC=C45
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InChI |
1S/C33H33NO3/c1-2-5-29(22-32(35)36)27-12-14-30(15-13-27)37-24-26-10-8-25(9-11-26)23-34-20-18-33(19-21-34)17-16-28-6-3-4-7-31(28)33/h3-4,6-17,29H,18-24H2,1H3,(H,35,36)/t29-/m0/s1
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InChIKey |
FHRWHNJJQGSCQC-LJAQVGFWSA-N
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CAS Number |
CAS 1292290-38-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Free fatty acid receptor 1 (GPR40) | Target Info | Modulator | [2] |
KEGG Pathway | Insulin secretion | |||
Reactome | G alpha (q) signalling events | |||
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Incretin Synthesis, Secretion, and Inactivation | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01358981) A Study of LY2881835 in Healthy People and People With Diabetes. U.S. National Institutes of Health. | |||
REF 2 | Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists. Front Endocrinol (Lausanne) 2014; 5: 137. |
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