Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0EH0S
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| Former ID |
DNC011335
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| Drug Name |
7-hydroxy-8-propionyl-2H-chromen-2-one
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| Synonyms |
7-hydroxy-8-propionyl-coumarin; CHEMBL1288557; 67752-18-5; 7-hydroxy-8-propionyl-2H-chromen-2-one; 7-hydroxy-8-propionylcoumarin
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H10O4
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| Canonical SMILES |
CCC(=O)C1=C(C=CC2=C1OC(=O)C=C2)O
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| InChI |
1S/C12H10O4/c1-2-8(13)11-9(14)5-3-7-4-6-10(15)16-12(7)11/h3-6,14H,2H2,1H3
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| InChIKey |
DVLIOVBNBOBBGS-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carbonic anhydrase IX (CA-IX) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Nitrogen metabolism | |||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
| Reactome | Regulation of gene expression by Hypoxia-inducible Factor | |||
| Reversible hydration of carbon dioxide | ||||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Reversible Hydration of Carbon Dioxide | ||||
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. | |||
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