Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E9JD
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| Former ID |
DIB020787
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| Drug Name |
quinoline 2
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| Synonyms |
quinoline 2; Tert-Butyl [(2s)-2-(2,5-Difluorophenyl)-3-(Quinolin-3-Yl)propyl]carbamate; GTPL8599; SCHEMBL20364499; tert-butyl N-[(2S)-2-(2,5-difluorophenyl)-3-quinolin-3-ylpropyl]carbamate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C23H24F2N2O2
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| Canonical SMILES |
CC(C)(C)OC(=O)NCC(CC1=CC2=CC=CC=C2N=C1)C3=C(C=CC(=C3)F)F
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| InChI |
1S/C23H24F2N2O2/c1-23(2,3)29-22(28)27-14-17(19-12-18(24)8-9-20(19)25)11-15-10-16-6-4-5-7-21(16)26-13-15/h4-10,12-13,17H,11,14H2,1-3H3,(H,27,28)/t17-/m1/s1
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| InChIKey |
IRFHMTUHTBSEBK-QGZVFWFLSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Insulin-degrading enzyme (IDE) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Alzheimer's disease | |||
| WikiPathways | Alzheimers Disease | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8599). | |||
| REF 2 | Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59. | |||
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