Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E7AZ
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| Former ID |
DIB021059
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| Drug Name |
tiotidine
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| Synonyms |
Tiotidine; TIOTIDINE; 69014-14-8; [3H]tiotidine; ICI 125,211; ICI-125211; Tiotidine [USAN:INN]; Tiotidinum [INN-Latin]; UNII-EZU9AIZ69M; Tiotidina [INN-Spanish]; EZU9AIZ69M; NCGC00163256-01; DSSTox_CID_26341; 2-Cyano-1-(2-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)ethyl)-3-methylguanidine; DSSTox_RID_81545; DSSTox_GSID_46341; Tiotidinum; Tiotidina; 2-guanidino-4-(2-(2-cyano-3-methylguanidino)ethylthiomethyl)thiazole; [3H]-tiotidine; Guanidine,; ICI 125,211
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C10H16N8S2
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| Canonical SMILES |
CN=C(NCCSCC1=CSC(=N1)N=C(N)N)NC#N
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| InChI |
1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18)
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| InChIKey |
YDDXVAXDYKBWDX-UHFFFAOYSA-N
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| CAS Number |
CAS 69014-14-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4746055, 11113722, 14850128, 22395698, 26756614, 34714865, 47207815, 47285824, 48029619, 49846382, 50065078, 50174732, 56464665, 57309564, 57313278, 85209333, 85788115, 91746436, 92308961, 103173478, 104294281, 124897822, 129778732, 135009327, 135651265, 135698100, 137262864, 140128370, 144205594, 162022584, 170466487, 176484000, 178100786, 179293855, 179339571, 180371818, 184548222, 198973299, 224814041, 226490403, 234749296, 241181916, 241377493, 249617212
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| ChEBI ID |
CHEBI:92190
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H2 receptor (H2R) | Target Info | Antagonist | [3], [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gastric acid secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Histamine H2 receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | |||
| Gastric Acid Production | ||||
| Reactome | Histamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Secretion of Hydrochloric Acid in Parietal Cells | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3959). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1235). | |||
| REF 3 | Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells. Br J Pharmacol. 1997 Nov;122(5):867-74. | |||
| REF 4 | Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. Mol Pharmacol. 2003 Aug;64(2):512-20. | |||
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