Drug Information
Drug General Information | Top | |||
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Drug ID |
D0E5DB
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Former ID |
DIB014056
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Drug Name |
Laromustine
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Synonyms |
Cloretazine; Onrigin; Alkylating agents, Vion; SHP, Vion; Sulfonyl hydrazine prodrugs, Vion; VN-40101M; VNP-40101M; VNP-4090-CE; 90CE
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 3 | [1] | |
Company |
Vion Pharmaceuticals Inc
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Structure |
Download2D MOL |
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Formula |
C6H14ClN3O5S2
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Canonical SMILES |
CNC(=O)N(N(CCCl)S(=O)(=O)C)S(=O)(=O)C
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InChI |
1S/C6H14ClN3O5S2/c1-8-6(11)10(17(3,14)15)9(5-4-7)16(2,12)13/h4-5H2,1-3H3,(H,8,11)
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InChIKey |
PVCULFYROUOVGJ-UHFFFAOYSA-N
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CAS Number |
CAS 173424-77-6
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Binder | [2] |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00112554) Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia. U.S. National Institutes of Health. | |||
REF 2 | Phase I study of temozolomide and laromustine (VNP40101M) in patients with relapsed or refractory leukemia. Clin Lymphoma Myeloma Leuk. 2010 Jun;10(3):211-6. |
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