Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E3FR
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| Former ID |
DIB020372
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| Drug Name |
ML297
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| Synonyms |
ML-297; ML 297
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C17H14F2N4O
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| Canonical SMILES |
CC1=NN(C(=C1)NC(=O)NC2=CC(=C(C=C2)F)F)C3=CC=CC=C3
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| InChI |
1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
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| InChIKey |
IEKSMUSSYJUQMY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inward rectifier potassium channel Kir3.1 (KCNJ3) | Target Info | Activator | [2] |
| KEGG Pathway | Circadian entrainment | |||
| Retrograde endocannabinoid signaling | ||||
| Glutamatergic synapse | ||||
| Cholinergic synapse | ||||
| Serotonergic synapse | ||||
| Dopaminergic synapse | ||||
| Estrogen signaling pathway | ||||
| Oxytocin signaling pathway | ||||
| Morphine addiction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| GABA-B receptor II signaling | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Activation of G protein gated Potassium channels | |||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | Calcium Regulation in the Cardiac Cell | |||
| G Protein Signaling Pathways | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7768). | |||
| REF 2 | ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86. | |||
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