Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E0CT
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| Former ID |
DIB007757
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| Drug Name |
Trimebutine
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| Synonyms |
Trimebutine maleate; Trimedat; Dromostat; Ibutin; Digerent polifarma; EINECS 251-845-9; TM 906; (1-Ethyl-1-phenyl-2-(3,4,5-trimethoxybenzoyloxy)ethyl)dimethylammonium hydrogen maleate; AC1O5HFA; Benzoic acid, 3,4,5-trimethoxy-, beta-(dimethylamino)-beta-ethylphenethyl ester, maleate (1:1); 34140-59-5; SCHEMBL1652810; C22H29NO5.C4H4O4; AKOS026750056; LS-38470; dimethyl-[2-phenyl-1-(3,4,5-trimethoxybenzoyl)oxybutan-2-yl]azanium; (E)-4-hydroxy-4-oxobut-2-enoate; Benzoic acid, 3,4,5-trimethoxy-, beta-(dimethylamino)-beta-ethyl
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| Drug Type |
Small molecular drug
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| Indication | Irritable bowel syndrome [ICD-11: DD91.0; ICD-10: K55-K64, K58; ICD-9: 564.1, 787.91] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C22H29NO5
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| Canonical SMILES |
CCC(COC(=O)C1=CC(=C(C(=C1)OC)OC)OC)(C2=CC=CC=C2)N(C)C
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| InChI |
1S/C22H29NO5/c1-7-22(23(2)3,17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5/h8-14H,7,15H2,1-6H3
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| InChIKey |
LORDFXWUHHSAQU-UHFFFAOYSA-N
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| CAS Number |
CAS 58997-89-0
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:94458
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.537; p = 0.013). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.624; p = 0.026). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.46; p = 0.023). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Odoribacter splanchnicus (log2FC = -0.691; p = 0.025). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Bifidobacterium ruminantium (log2FC = -0.466; p = 0.027). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -0.979; p = 0.024). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -0.414; p = 0.013). | |||
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Studied Microbe: Salmonella typhimurium LT2
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Salmonella typhimurium LT2 (log2FC = -0.458; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium spiroforme DSM1552
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -0.374; p = 0.044). | |||
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Studied Microbe: Eubacterium biforme DSM 3989
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.712; p = 0.016). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -0.337; p = 0.014). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.678; p = 0.01). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -0.726; p = 0.009). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -0.691; p = 0.009). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -0.443; p = 0.04). | |||
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Studied Microbe: Clostridium sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Clostridium sp. (log2FC = -0.787; p = 0.003). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Eubacterium hallii DSM3353 (log2FC = -0.496; p = 0.007). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -0.469; p = 0.011). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -0.581; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -0.436; p = 0.016). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -0.407; p = 0.021). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -0.354; p = 0.033). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimebutine maleate can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -0.808; p = 0.015). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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