Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0DW2F
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| Former ID |
DNC009673
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| Drug Name |
5-fluoro-6-iodo-UMP
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| Synonyms |
SCHEMBL1364021
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C9H11FIN2O9P
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| Canonical SMILES |
C(C1C(C(C(O1)N2C(=C(C(=O)NC2=O)F)I)O)O)OP(=O)(O)O
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| InChI |
1S/C9H11FIN2O9P/c10-3-6(11)13(9(17)12-7(3)16)8-5(15)4(14)2(22-8)1-21-23(18,19)20/h2,4-5,8,14-15H,1H2,(H,12,16,17)(H2,18,19,20)/t2-,4-,5-,8-/m1/s1
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| InChIKey |
NJSVPTGGTXIMLP-UMMCILCDSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Orotidine 5'-monophosphate decarboxylase (UMPS) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||
| Superpathway of pyrimidine ribonucleotides de novo biosynthesis | ||||
| UMP biosynthesis | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. | |||
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