Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0DR4W
|
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| Former ID |
DIB001030
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| Drug Name |
MyoCell SDF-1
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| Synonyms |
Autologous skeletal myoblast therapy (SDF-1, cardiovascular disease), Bioheart
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|
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Phase 3 | [1] | |
| Company |
Bioheart
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Stromal cell-derived factor 1 (CXCL12) | Target Info | Modulator | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| NF-kappa B signaling pathway | ||||
| Axon guidance | ||||
| Leukocyte transendothelial migration | ||||
| Intestinal immune network for IgA production | ||||
| Pathways in cancer | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | IL-7 Signaling Pathway | |||
| TWEAK Signaling Pathway | ||||
| Panther Pathway | Axon guidance mediated by Slit/Robo | |||
| Pathway Interaction Database | CXCR4-mediated signaling events | |||
| Syndecan-4-mediated signaling events | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Nuclear signaling by ERBB4 | |||
| Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | EV release from cardiac cells and their functional effects | |||
| Signaling by ERBB4 | ||||
| Allograft Rejection | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021307) | |||
| REF 2 | Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine. Expert Opin Biol Ther. 2011 Feb;11(2):189-97. | |||
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