Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0DQ6Z
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| Former ID |
DNC000027
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| Drug Name |
1,4-Naphthoquinone
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| Synonyms |
1,4-NAPHTHOQUINONE; 130-15-4; naphthalene-1,4-dione; p-Naphthoquinone; NAPHTHOQUINONE; alpha-Naphthoquinone; 1,4-Naphthylquinone; USAF CY-10; 1,4-dihydronaphthalene-1,4-dione; 1,4-Dihydro-1,4-diketonaphthalene; 1,4-Naftochinon; RCRA waste number U166; UNII-RBF5ZU7R7K; NSC 9583; 1,4-Naftochinon [Czech]; 1,4-Naphthaquinone; CCRIS 5424; HSDB 2037; EINECS 204-977-6; RBF5ZU7R7K; RCRA waste no U166; CHEMBL55934; AI3-24292; NQ-1; CHEBI:27418; NSC9583; FRASJONUBLZVQX-UHFFFAOYSA-N; MFCD00001676; 1,4-naphtho-quinone
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H6O2
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| Canonical SMILES |
C1=CC=C2C(=O)C=CC(=O)C2=C1
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| InChI |
1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H
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| InChIKey |
FRASJONUBLZVQX-UHFFFAOYSA-N
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| CAS Number |
CAS 130-15-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5602, 75035, 588830, 600877, 3136613, 5943270, 8139885, 8156025, 10506347, 10852286, 11371688, 11374908, 11484077, 11488297, 11490570, 11493059, 12055864, 14793918, 17425041, 24849257, 26679313, 26757484, 29204424, 29227205, 32581857, 38374893, 48259572, 49996619, 50111628, 53787433, 56269727, 56370075, 57325077, 57390733, 77852366, 85247019, 87573450, 88811914, 93618177, 102851577, 103240920, 103811485, 104318097, 109454404, 117586811, 124637355, 125275433, 125339839, 126545966, 126677177
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| ChEBI ID |
CHEBI:27418
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | Inhibitor | [2] |
| Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [1] | |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Tryptophan metabolism | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Tryptophan Metabolism | ||||
| Reactome | Pyrimidine biosynthesis | |||
| Tryptophan catabolism | ||||
| WikiPathways | Metabolism of nucleotides | |||
| Tryptophan metabolism | ||||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. | |||
| REF 2 | Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. | |||
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