Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0DP0J
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| Drug Name |
PR-924
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| Indication | T lymphoblastic leukaemia [ICD-11: 2B33.4; ICD-10: C91-C95] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C37H38N4O5
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| Canonical SMILES |
CC1=C(CC2=CC=CC=C12)C(=O)NC(C)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)C6(CO6)C
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| InChI |
1S/C37H38N4O5/c1-22-27-14-8-7-13-25(27)18-29(22)35(44)39-23(2)34(43)41-32(19-26-20-38-30-16-10-9-15-28(26)30)36(45)40-31(33(42)37(3)21-46-37)17-24-11-5-4-6-12-24/h4-16,20,23,31-32,38H,17-19,21H2,1-3H3,(H,39,44)(H,40,45)(H,41,43)/t23-,31+,32+,37-/m1/s1
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| InChIKey |
ADBUEVSHEJICCM-LZNHGOJSSA-N
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| CAS Number |
CAS 1416709-79-9
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| PubChem Compound ID | ||||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo. Br J Haematol. 2011 Jan;152(2):155-63. | |||
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