Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0DN1I
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| Former ID |
DIB014085
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| Drug Name |
JTT-551
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| Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Terminated | [1] | |
| Company |
Japan Tobacco Inc
|
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| Structure |
 |
Download2D MOL
|
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| Formula |
C34H43N3O3S2
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| Canonical SMILES |
CCCC(CCC)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=CSC(=N3)CN(CC4=NC=C(S4)C(C)(C)C)CC(=O)O
|
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| InChI |
1S/C34H43N3O3S2/c1-6-8-25(9-7-2)26-14-16-28(17-15-26)40-22-24-10-12-27(13-11-24)29-23-41-32(36-29)20-37(21-33(38)39)19-31-35-18-30(42-31)34(3,4)5/h10-18,23,25H,6-9,19-22H2,1-5H3,(H,38,39)
|
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| InChIKey |
FKGBFRNVTCFMGU-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein-tyrosine phosphatase 1B (PTP1B) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Adherens junction | |||
| Insulin signaling pathway | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Panther Pathway | Cadherin signaling pathway | |||
| Pathway Interaction Database | Insulin Pathway | |||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | ||||
| Signaling events mediated by PTP1B | ||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||||
| Signaling events mediated by TCPTP | ||||
| IGF1 pathway | ||||
| EGF receptor (ErbB1) signaling pathway | ||||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| PDGFR-beta signaling pathway | ||||
| N-cadherin signaling events | ||||
| Reactome | Integrin alphaIIb beta3 signaling | |||
| Regulation of IFNG signaling | ||||
| Regulation of IFNA signaling | ||||
| Growth hormone receptor signaling | ||||
| WikiPathways | Insulin Signaling | |||
| Growth hormone receptor signaling | ||||
| Leptin signaling pathway | ||||
| Interferon gamma signaling | ||||
| Interferon alpha/beta signaling | ||||
| Integrin alphaIIb beta3 signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. J Diabetes Res. 2014;2014:680348. | |||
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