Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0DK8V
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| Former ID |
DAP000323
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| Drug Name |
Cetirizine
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| Synonyms |
Cetiderm; Cetirizin; Cetirizina; Cetirizinum; Cetryn; Setir; Virlix; Ziptek; Zirtek; Zyrlex; Cetirizina [Spanish]; Cetirizinum [Latin]; Cetrizine Hcl; Hitrizin Film Tablet; Cetiderm (TN); Cetirizine (INN); Cetirizine [INN:BAN]; P-071; Reactine (TN); Zyrtec (TN); [(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethyl)oxy]acetic acid; (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid; (2-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-acetic acid; (2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid; 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid; 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
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| Drug Type |
Small molecular drug
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| Indication | Allergic rhinitis [ICD-11: CA08.0] | Approved | [1], [2] | |
| Therapeutic Class |
Antiallergic Agents
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| Company |
Pfizer Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C21H25ClN2O3
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| Canonical SMILES |
C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
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| InChI |
1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)
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| InChIKey |
ZKLPARSLTMPFCP-UHFFFAOYSA-N
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| CAS Number |
CAS 83881-51-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9980, 853774, 5658851, 7978899, 8151737, 11466531, 11467651, 11486082, 11501857, 14756386, 29221835, 46508368, 47359454, 47583265, 47953980, 48179259, 48403972, 48415747, 49698526, 49846704, 49861380, 50112918, 50112919, 50112920, 50276923, 51091966, 57321395, 57581408, 81041207, 85209379, 85788875, 90341832, 92290962, 92721266, 93624540, 103266652, 104170194, 104301286, 108136263, 117611598, 117843325, 121362416, 124526347, 125324646, 125339821, 125544920, 125822846, 126525325, 126582564, 126619301
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| ChEBI ID |
CHEBI:3561
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| ADReCS Drug ID | BADD_D00417 ; BADD_D00418 | |||
| SuperDrug ATC ID |
R06AE07
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| SuperDrug CAS ID |
cas=083881510
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.387; p = 0.015). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -0.57; p = 0.004). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.415; p = 0.006). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.957; p = 0.004). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.539; p = 0.011). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -0.404; p = 0.023). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.877; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.773; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.633; p = 0.018). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.593; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.716; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.687; p = 0.019). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.759; p = 0.002). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -0.349; p = 0.04). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.641; p = 0.012). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.493; p = 0.013). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.688; p = 0.011). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.704; p = 0.009). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.823; p = 0.015). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.895; p = 0.007). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.57; p = 0.004). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.811; p = 0.004). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.552; p = 0.011). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Salmonella typhimurium LT2
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Salmonella typhimurium LT2 (log2FC = -0.34; p = 0.012). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Eubacterium biforme DSM 3989
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.474; p = 0.016). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -0.434; p = 0.03). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.504; p = 0.013). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -0.333; p = 0.039). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cetirizine can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -0.431; p = 0.025). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [4], [5] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1222). | |||
| REF 2 | Comparative tolerability of second generation antihistamines. Drug Saf. 1999 May;20(5):385-401. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted) aryl-6-[(substituted aryl) amino] pyrimidines. Arzneimittelforschung. 2009;59(5):243-7. | |||
| REF 5 | Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. | |||
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