Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0DI0B
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| Former ID |
DIB000757
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| Drug Name |
OX 19
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| Synonyms |
Sublingual desmopressin
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| Indication | Urinary incontinence [ICD-11: MF50.2; ICD-9: 788.3] | Discontinued in Phase 1 | [1] | |
| Company |
Orexo
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Vasopressin V2 receptor (V2R) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Vasopressin-regulated water reabsorption | ||||
| Pathwhiz Pathway | Vasopressin Regulation of Water Homeostasis | |||
| Pathway Interaction Database | Arf6 trafficking events | |||
| Reactome | Vasopressin-like receptors | |||
| G alpha (s) signalling events | ||||
| Vasopressin regulates renal water homeostasis via Aquaporins | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Regulation of Water Balance by Renal Aquaporins | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021110) | |||
| REF 2 | Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. | |||
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