Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D6ZK
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| Former ID |
DIB008421
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| Drug Name |
15(S)-hydroxyeicosatetraenoic acid (ophthalmic, dry eye), Alcon
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| Synonyms |
PROCALYX; 15(S)-HETE; 15(S)-Hydroxyeicosatetraenoic acid
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| Drug Type |
Small molecular drug
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| Indication | Ocular disease [ICD-11: N.A.] | Discontinued in Phase 3 | [1], [2] | |
| Company |
Alcon Inc
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| Structure |
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Download2D MOL |
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| Formula |
C20H32O3
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| Canonical SMILES |
CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O
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| InChI |
1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
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| InChIKey |
JSFATNQSLKRBCI-VAEKSGALSA-N
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| CAS Number |
CAS 54845-95-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7313, 4266108, 7978572, 8143211, 8616377, 14850504, 15469965, 24895431, 26754749, 26754750, 39289773, 47364906, 47364907, 50110769, 57357854, 74419692, 92309753, 96025614, 99300667, 99302185, 103719170, 104046390, 113853868, 126524931, 135202767, 135651378, 137095123, 142102002, 142970209, 160846582, 162228061, 164150639, 164792401, 179205504, 198935864, 227250004, 241094668, 252370899, 252455477, 252464208
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| ChEBI ID |
CHEBI:15558
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Mucin (MUC) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3401). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019901) | |||
| REF 3 | 15(S)-hydroxyeicosatetraenoic acid (15-HETE), a product of arachidonic acid peroxidation, is an active component of hemozoin toxicity to monocytes. Parassitologia. 1999 Sep;41(1-3):199-202. | |||
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