Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D4NX
|
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| Drug Name |
PMID25666693-Compound-108
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cancer related pain [ICD-11: MG30; ICD-10: R52.1, R52.2] | Patented | [1] | |
| Inflammatory pain [ICD-11: MG30.42; ICD-10: R52, G89] | Patented | [1] | ||
| Neuropathic pain [ICD-11: 8E43.0] | Patented | [1] | ||
| Osteoarthritis pain [ICD-11: MG30.31] | Patented | [1] | ||
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H24ClN3OSi
|
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| Canonical SMILES |
C[Si](C)(C)C1=CC=C(C=C1)NC(=O)C2=CCN(CC2)C3=C(C=CC=N3)Cl
|
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| InChI |
1S/C20H24ClN3OSi/c1-26(2,3)17-8-6-16(7-9-17)23-20(25)15-10-13-24(14-11-15)19-18(21)5-4-12-22-19/h4-10,12H,11,13-14H2,1-3H3,(H,23,25)
|
|||
| InChIKey |
DYKDTFQPEROGHZ-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Transient receptor potential cation channel V1 (TRPV1) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. | |||
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