Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D3KY
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Former ID |
DIB003706
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Drug Name |
SC-106
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Synonyms |
SC-106; AC1LAPZA; SCHEMBL6773940; IABCGGIFHPDBCJ-JTQLQIEISA-N; (3R)-3-[[2-[(3-guanidinobenzoyl)amino]acetyl]amino]pent-4-ynoic acid; (R)-3-(2-{[1-(3-Guanidino-phenyl)-methanoyl]-amino}-ethanoylamino)-pent-4-ynoic acid; (3R)-3-[[2-[[3-(diaminomethylideneamino)benzoyl]amino]acetyl]amino]pent-4-ynoic acid
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Drug Type |
Small molecular drug
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Indication | Rheumatoid arthritis [ICD-11: FA20] | Discontinued in Phase 2 | [1] | |
Company |
Scotia Holdings plc
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Structure |
Download2D MOL |
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Formula |
C15H17N5O4
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Canonical SMILES |
C#CC(CC(=O)O)NC(=O)CNC(=O)C1=CC(=CC=C1)N=C(N)N
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InChI |
1S/C15H17N5O4/c1-2-10(7-13(22)23)19-12(21)8-18-14(24)9-4-3-5-11(6-9)20-15(16)17/h1,3-6,10H,7-8H2,(H,18,24)(H,19,21)(H,22,23)(H4,16,17,20)/t10-/m0/s1
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InChIKey |
IABCGGIFHPDBCJ-JTQLQIEISA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Phospholipase A2 (PLA2G1B) | Target Info | Inhibitor | [2] |
BioCyc | Phospholipases | |||
KEGG Pathway | Glycerophospholipid metabolism | |||
Ether lipid metabolism | ||||
Arachidonic acid metabolism | ||||
Linoleic acid metabolism | ||||
alpha-Linolenic acid metabolism | ||||
Metabolic pathways | ||||
Ras signaling pathway | ||||
Vascular smooth muscle contraction | ||||
Pancreatic secretion | ||||
Fat digestion and absorption | ||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
Reactome | Acyl chain remodelling of PC | |||
Acyl chain remodelling of PE | ||||
Acyl chain remodelling of PI | ||||
WikiPathways | Glycerophospholipid biosynthesis |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007225) | |||
REF 2 | US patent application no. 6,673,908, Tumor necrosis factor receptor 2. |
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