Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D3DU
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| Former ID |
DNC000933
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| Drug Name |
Methotrexate Sodium
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| Synonyms |
Methotrexate disodium salt; 7413-34-5; Sodium methotrexate; MTX disodium; methotrexate disodium; UNII-3IG1E710ZN; 3IG1E710ZN; CHEBI:50679; Amethopterin sodium; Disodium methotrexate; Methotrexat dinatrium; Mexate-Aq Preserved; Methotrexate sodium salt; EINECS 231-022-0; 59-05-2 (Parent); Methotrexate Preservative Free; 4-Amino-N(sup 10)-methylpteroylglutamic acid disodium salt; METHOTREXATE SODIUM PRESERVATIVE FREE
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Approved | [1] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Hospira Inc
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| Structure |
 |
Download2D MOL
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| Formula |
C20H20N8Na2O5
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| Canonical SMILES |
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
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| InChI |
1S/C20H22N8O5.2Na/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);;/q;2*+1/p-2/t13-;;/m0../s1
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| InChIKey |
DASQOOZCTWOQPA-GXKRWWSZSA-L
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| CAS Number |
CAS 7413-34-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5042, 67627, 585459, 585463, 602572, 826993, 831594, 835286, 836777, 837147, 3138774, 7847210, 7889076, 7979933, 8028432, 8029193, 8029470, 8149420, 10241686, 10321387, 11110523, 11113978, 11120366, 11120854, 11121342, 11335289, 11360528, 11364750, 11367312, 11369874, 11371593, 11374311, 11378039, 11447411, 11461500, 11466163, 11467283, 11484830, 11485885, 11488893, 11490313, 11492431, 11495650, 14760074, 14808762, 17404585, 22395177, 24897373, 24902354, 26680792
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| ChEBI ID |
CHEBI:50679
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| ADReCS Drug ID | BADD_D01419 | |||
| SuperDrug ATC ID |
L01BA01; L04AX03
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| SuperDrug CAS ID |
cas=000059052
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dihydrofolate reductase (DHFR) | Target Info | Modulator | [2] |
| KEGG Pathway | One carbon pool by folate | |||
| Folate biosynthesis | ||||
| Metabolic pathways | ||||
| Panther Pathway | Tetrahydrofolate biosynthesis | |||
| Formyltetrahydroformate biosynthesis | ||||
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Pathway Interaction Database | E2F transcription factor network | |||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| WikiPathways | Nucleotide Metabolism | |||
| Trans-sulfuration and one carbon metabolism | ||||
| Retinoblastoma (RB) in Cancer | ||||
| One Carbon Metabolism | ||||
| Metabolism of water-soluble vitamins and cofactors | ||||
| Metabolism of nitric oxide | ||||
| Folate Metabolism | ||||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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