Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D3CJ
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Former ID |
DIB006034
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Drug Name |
BYK-191023
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Synonyms |
INOS inhibitors (inflammatory diseases); INOS inhibitors (inflammatory diseases), Altana; INOS inhibitors (inflammatory diseases), Nycomed
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Drug Type |
Small molecular drug
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Indication | Inflammation [ICD-11: 1A00-CA43.1] | Investigative | [1] | |
Company |
Nycomed
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Structure |
Download2D MOL |
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Formula |
C14H14N4O
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Canonical SMILES |
COC1=CC(=NC=C1)CCC2=NC3=C(N2)C=CC=N3
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InChI |
1S/C14H14N4O/c1-19-11-6-8-15-10(9-11)4-5-13-17-12-3-2-7-16-14(12)18-13/h2-3,6-9H,4-5H2,1H3,(H,16,17,18)
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InChIKey |
YBOCDKFRGBOOFO-UHFFFAOYSA-N
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CAS Number |
CAS 608880-48-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Nitric-oxide synthase inducible (NOS2) | Target Info | Inhibitor | [1] |
BioCyc | Citrulline-nitric oxide cycle | |||
KEGG Pathway | Arginine biosynthesis | |||
Arginine and proline metabolism | ||||
Metabolic pathways | ||||
Calcium signaling pathway | ||||
HIF-1 signaling pathway | ||||
Peroxisome | ||||
Salmonella infection | ||||
Pertussis | ||||
Leishmaniasis | ||||
Chagas disease (American trypanosomiasis) | ||||
Toxoplasmosis | ||||
Amoebiasis | ||||
Tuberculosis | ||||
Pathways in cancer | ||||
Small cell lung cancer | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
IL2 Signaling Pathway | ||||
Pathway Interaction Database | IL12-mediated signaling events | |||
Alpha9 beta1 integrin signaling events | ||||
ATF-2 transcription factor network | ||||
IL23-mediated signaling events | ||||
Signaling mediated by p38-alpha and p38-beta | ||||
HIF-1-alpha transcription factor network | ||||
Reactome | ROS production in response to bacteria | |||
Nitric oxide stimulates guanylate cyclase | ||||
WikiPathways | Type II interferon signaling (IFNG) | |||
Spinal Cord Injury | ||||
AGE/RAGE pathway | ||||
Effects of Nitric Oxide |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1250). |
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