Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D2PJ
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| Former ID |
DNC013009
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| Drug Name |
GNF-PF-4421
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| Synonyms |
GNF-PF-4421; 85418-73-1; 6-Ethyl-4-hydroxyquinoline-3-carboxylic acid ethyl ester; AURORA 17945; ethyl 6-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate; ethyl 6-ethyl-4-hydroxyquinoline-3-carboxylate; AC1LECY7; Oprea1_563397; Oprea1_408052; CHEMBL206540; SCHEMBL7291769; SCHEMBL11066821; CTK8F7131; DTXSID00350618; ZFOFJXFVCJQXBL-UHFFFAOYSA-N; MolPort-003-761-637; MolPort-000-653-080; ZINC9761169; STK791819; MMV007116; STK942448; 3-Quinolinecarboxylic acid, 6-ethyl-1,4-dihydro-4-oxo-, ethyl ester; AKOS002674049; AKOS001717599
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H15NO3
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| Canonical SMILES |
CCC1=CC2=C(C=C1)NC=C(C2=O)C(=O)OCC
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| InChI |
1S/C14H15NO3/c1-3-9-5-6-12-10(7-9)13(16)11(8-15-12)14(17)18-4-2/h5-8H,3-4H2,1-2H3,(H,15,16)
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| InChIKey |
ZFOFJXFVCJQXBL-UHFFFAOYSA-N
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| CAS Number |
CAS 85418-73-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. | |||
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