Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D2MS
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Former ID |
DNC008408
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Drug Name |
5-methylenearisteromycin
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Synonyms |
CHEMBL262063; 5-methylenearisteromycin; 5'-Methylenearisteromycin; BDBM50373100
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C12H15N5O3
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Canonical SMILES |
C=C1C(C(C(C1N2C=NC3=C(N=CN=C32)N)O)O)CO
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InChI |
1S/C12H15N5O3/c1-5-6(2-18)9(19)10(20)8(5)17-4-16-7-11(13)14-3-15-12(7)17/h3-4,6,8-10,18-20H,1-2H2,(H2,13,14,15)/t6-,8+,9+,10-/m0/s1
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InChIKey |
REGXGANNNMTWAW-ZQNVIIHSSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adenosylhomocysteinase (AHCY) | Target Info | Inhibitor | [1] |
BioCyc | Superpathway of methionine degradation | |||
Methionine degradation | ||||
Cysteine biosynthesis | ||||
KEGG Pathway | Cysteine and methionine metabolism | |||
Metabolic pathways | ||||
Pathwhiz Pathway | Selenoamino Acid Metabolism | |||
Betaine Metabolism | ||||
Methionine Metabolism | ||||
WikiPathways | Metabolism of amino acids and derivatives | |||
Trans-sulfuration and one carbon metabolism | ||||
One Carbon Metabolism | ||||
Trans-sulfuration pathway | ||||
Phase II conjugation | ||||
Folate Metabolism |
References | Top | |||
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REF 1 | Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem. 2008 Apr 1;16(7):3809-15. |
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