Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D2EF
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| Former ID |
DNC000013
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| Drug Name |
(R)-nipecotic acid
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| Synonyms |
(R)-piperidine-3-carboxylic acid; 25137-00-2; (R)-(-)-Nipecotic acid; (3R)-piperidine-3-carboxylic acid; (R)-(-)-3-Piperidinecarboxylic acid; (-)-nipecotic acid; (3R)-nipecotic acid; (3R)-(-)-piperidine-3-carboxylic acid; D(-)-Nipecotic acid; r-(-)-3-piperidinecarboxylic acid; 3-Piperidinecarboxylic acid, (R)-; (R)-hexahydronicotinic acid; (R)-(-)-piperidine-3-carboxylic acid; (-)-hexahydronicotinic acid; (3R)-hexahydronicotinic acid; CHEMBL77575; (r)-3-piperidinecarboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H11NO2
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| Canonical SMILES |
C1CC(CNC1)C(=O)O
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| InChI |
1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m1/s1
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| InChIKey |
XJLSEXAGTJCILF-RXMQYKEDSA-N
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| CAS Number |
CAS 25137-00-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11110662, 11113421, 11645753, 24884154, 50396594, 57370950, 84942882, 85420544, 87573989, 88813195, 92716493, 103276853, 103931606, 114627262, 117683365, 124878988, 126580358, 126589901, 126608713, 126622904, 126638950, 126654364, 126662892, 126737575, 129697673, 132520772, 134350074, 135596723, 135693752, 136377080, 136903712, 137203248, 143053596, 151993926, 152250404, 160800639, 162079079, 162114961, 162173221, 162546525, 163805310, 164203094, 164813855, 165237009, 170502339, 172913596, 172914038, 174475867, 174529836, 179235855
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| ChEBI ID |
CHEBI:60120
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA transporter GAT-1 (SLC6A1) | Target Info | Inhibitor | [2] |
| Gamma-aminobutyric acid uptake (GABAU) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | GABAergic synapse | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr Pharm Des. 2000 Aug;6(12):1193-209. | |||
| REF 2 | Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem. 2004 Nov 4;47(23):5620-9. | |||
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