Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0CW1P
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| Former ID |
DAP001043
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| Drug Name |
Betamethasone
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| Synonyms |
betamethasone; 378-44-9; Betadexamethasone; Flubenisolone; Betamethazone; Rinderon; Visubeta; Celestene; Betnelan; Betapredol; Betacortril; Betacorlan; Methazon; Betsolan; Betamamallet; Hormezon; Betasolon; Betametasone; Cidoten; Bebate; Bedifos; Becort; beta-Methasone; Desacort-Beta; Rinderon A; beta-Methasone alcohol; Betametasona; Betafluorene; Betamethasonum; Celestone; Betamethasone cream; Betamethasone alcohol; Betametasone [DCIT]; 9alpha-Fluoro-16beta-methylprednisolone; Celestone Syrup and Tablets; Celeston; Celestona; Cellestoderm; Luxiqo; Betamethasone Base; Betamethasone Valearate; Betamethasonvalerat Mikron; LT00441022; SCH 4831; Beta-Methasone; Beta-Methasone alcohol; Betametasona [INN-Spanish]; Betamethasonum [INN-Latin]; Betnovate (TN); Celestone (TN); Diprolene (TN); Diprosone (TN); Lotrisone (TN); Rinderon (TN); SCH-4831; Betamethasone (JP15/USP/INN); Betamethasone [USAN:BAN:INN:JAN]; Betamethasone [USAN:INN:BAN:JAN]; Celestone, Betadexamethasone, Flubenisolone, Sch-4831, NCS-39470, Betamethasone; 1,4-Pregnadiene-3,20-dione-9alpha-fluoro-16 beta-methyl-11 beta,17alpha,21-triol; 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione; 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-16beta-methylprednisolone; 9-alpha-Fluoro-16-beta-methylprednisolone; 9alpha-Fluoro-16 beta-methyl-prednisolone; Betamethasone sodium phosphate
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| Drug Type |
Small molecular drug
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| Indication | Inflammation [ICD-11: 1A00-CA43.1] | Approved | [1], [2] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
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Download2D MOL |
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| Formula |
C22H29FO5
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| Canonical SMILES |
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
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| InChI |
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
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| InChIKey |
UREBDLICKHMUKA-DVTGEIKXSA-N
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| CAS Number |
CAS 378-44-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9066, 625879, 3161499, 7847310, 7978781, 8157046, 10321659, 11466390, 11467510, 11486140, 12159278, 14756597, 15004923, 24278276, 24860978, 24892150, 26757820, 29228348, 46500420, 46505155, 46530919, 47193705, 47499670, 47720710, 47720711, 47943900, 48019043, 48415627, 49698457, 50019449, 50111677, 53789445, 56320847, 56462985, 57288752, 57649117, 57653954, 75637045, 85788058, 87564725, 87568418, 92125449, 93167065, 103188847, 103914147, 104253177, 104321493, 121363120, 124757297, 124800522
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| ChEBI ID |
CHEBI:3077
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| ADReCS Drug ID | BADD_D00260 | |||
| SuperDrug ATC ID |
A07EA04; C05AA05; D07AC01; D07XC01; H02AB01; R01AD06; R03BA04; S01BA06; S01CB04; S02BA07; S03BA03
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| SuperDrug CAS ID |
cas=000378449
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.325; p = 0.014). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.614; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -1.012; p = 0.016). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.821; p = 0.04). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.333; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.582; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.623; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.576; p = 0.047). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.467; p = 0.002). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.356; p = 0.009). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.43; p = 0.017). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Odoribacter splanchnicus (log2FC = -0.553; p = 0.004). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.668; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.423; p = 0.036). | |||
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Studied Microbe: Clostridium sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone acetate can be metabolized by Clostridium sp. (log2FC = -0.369; p = 0.012). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [4] | |||
| Metabolic Reaction | Reduction | |||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone can be metabolized by gut microbiota through reduction. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucocorticoid receptor (NR3C1) | Target Info | Agonist | [5] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| Signaling events mediated by HDAC Class II | ||||
| FOXA2 and FOXA3 transcription factor networks | ||||
| Glucocorticoid receptor regulatory network | ||||
| Regulation of Androgen receptor activity | ||||
| AP-1 transcription factor network | ||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| SIDS Susceptibility Pathways | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Endoderm Differentiation | ||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
| Adipogenesis | ||||
| Circadian Clock | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7061). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019137. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 5 | The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur J Pharmacol. 2006 Aug 7;542(1-3):179-83. | |||
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