Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0CE6C
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| Drug Name |
LMI070
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| Synonyms |
branaplam; Branaplam; 1562338-42-4; NVS-SM1; UNII-P12R69543A; LMI-070; P12R69543A; 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol; Branaplam [INN]; SCHEMBL15475826; LMI070 (NVS-SM1); STWTUEAWRAIWJG-UHFFFAOYSA-N; BCP19909; ZINC146605125; AKOS030526592; CS-5319; HY-19620; Phenol, 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethyl-4-piperidinyl)oxy)-3-pyridazinyl)-
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| Indication | Spinal muscular atrophy [ICD-11: 8B61] | Phase 3 | [1] | |
| Company |
Novartis Pharmaceuticals East Hanover, NJ
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| Structure |
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Download2D MOL |
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| Formula |
C22H27N5O2
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| Canonical SMILES |
CC1(CC(CC(N1)(C)C)OC2=NN=C(C=C2)C3=C(C=C(C=C3)C4=CNN=C4)O)C
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| InChI |
1S/C22H27N5O2/c1-21(2)10-16(11-22(3,4)27-21)29-20-8-7-18(25-26-20)17-6-5-14(9-19(17)28)15-12-23-24-13-15/h5-9,12-13,16,27-28H,10-11H2,1-4H3,(H,23,24)
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| InChIKey |
STWTUEAWRAIWJG-UHFFFAOYSA-N
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| CAS Number |
CAS 1562338-42-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Survival motor neuron protein (SMN1) | Target Info | Modulator | [1] |
| KEGG Pathway | RNA transport | |||
| WikiPathways | Metabolism of non-coding RNA | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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