Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0CE5B
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| Former ID |
DIB018476
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| Drug Name |
135PAM1
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| Synonyms |
135PAM1; GTPL8343; 3-[3,5-bis(trifluoromethyl)phenyl]-1-[(3,4-dichlorophenyl)methyl]-1-[2-(5-methoxy-1H-indol-3-yl)ethyl]urea
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C27H21Cl2F6N3O2
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| Canonical SMILES |
COC1=CC2=C(C=C1)NC=C2CCN(CC3=CC(=C(C=C3)Cl)Cl)C(=O)NC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F
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| InChI |
1S/C27H21Cl2F6N3O2/c1-40-20-3-5-24-21(12-20)16(13-36-24)6-7-38(14-15-2-4-22(28)23(29)8-15)25(39)37-19-10-17(26(30,31)32)9-18(11-19)27(33,34)35/h2-5,8-13,36H,6-7,14H2,1H3,(H,37,39)
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| InChIKey |
FAXDMTURZKFXIY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Relaxin-3 receptor 1 (RXFP3) | Target Info | Modulator (allosteric modulator) | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8343). | |||
| REF 2 | In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. PLoS One. 2012;7(2):e30792. | |||
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