Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0C9JJ
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| Former ID |
DNCL002405
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| Drug Name |
AR-12
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| Synonyms |
2-Amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide; OSU-03012; 742112-33-0; OSU 03012; OSU03012; PDK1 inhibitor AR-12; OSU-03012 (AR-12); UNII-EX3O2Q61UV; 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide; AR 12; EX3O2Q61UV; CHEMBL1650595; 2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide; 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide; PubChem22592; MLS006010170; SCHEMBL570472; GTPL8005; C26H19F3N4O; EX-A253; DTXSID50225206; CHEBI:131196; MolPort-009-019-120
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| Drug Type |
Small molecular drug
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| Indication | Lymphoma [ICD-11: 2A80-2A86; ICD-9: 202.8, 208.9] | Phase 1 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C26H19F3N4O
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| Canonical SMILES |
C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F
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| InChI |
1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34)
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| InChIKey |
YULUCECVQOCQFQ-UHFFFAOYSA-N
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| CAS Number |
CAS 742112-33-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
15008861, 22455284, 44144352, 77529760, 99436984, 124757004, 124966544, 125163809, 125335329, 131480760, 134222632, 134964418, 136367304, 136367847, 137248109, 137750678, 143499298, 144116327, 152234784, 152258252, 152344384, 160647088, 162011464, 162037439, 162205107, 163893414, 164159505, 172131582, 172650377, 174006452, 174530327, 174530328, 180096554, 186014822, 198945474, 223704779, 226877051, 242059900, 247295286, 249565685, 249871551, 252215975, 252438951
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| ChEBI ID |
CHEBI:131196
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8005). | |||
| REF 2 | ClinicalTrials.gov (NCT00978523) Study of AR-12 (2-Amino-N-[4-[5-(2 Phenanthrenyl)-3-(Trifluoromethyl)-1H-pyrazol-1-yl] Phenyl]-Acetamide) in Adult Patients With Advanced or Recurrent Solid Tumors orLymphoma. U.S. National Institutes of Health. | |||
| REF 3 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | |||
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